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pentobarbital will lessen the extent or result of vinorelbine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unknown.pentobarbital decreases levels of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Strong CYP3A4 inducers can decrease panobinostat levels by ~70% and bring about